|MOL ECULAR PR OPERTIES O PTIMIZATION PROJECT|
SLIPPER is a program complex for prediction aqueous Solubility (logS), LIPophilicity and oral absorption of drugs in humans (FA) for different types of compounds on the basis of their structural and phisicochemical similarity. The current version of the program SLIPPER calculates lipophilicity (including a profile of LogP-pH dependence ) and solubility in water ( including a profile of logSw-pH dependence ). SLIPPER allows you to calculate all the aforementioned values both for a single compound and for a database containing hundreds thousand of compounds. On the basis of the specified methodology calculation of three important properties of ADME SLIPPER-2001 allows you to calculate all the aforementioned properties for single compounds and also for databases containing hundreds of thousands. It is possible to receive the detailed information for each medicines. Results of calculations may be saved in *.doc, *.sdf, *.xls or *.txt formats. SLIPPER may be useful for chemists, biochemists, ecologists, molecular biologists, medicinal chemists and pharmacologists operating with huge databases.